Leucine-sensitive hypoglycaemia treated with diazoxide.

It has been estimated that about one-third of children with so-called idiopathic hypoglycaemia are leucine sensitive (Mabry, Di George, and Auerbach, 1960). However, the total number of leucine-sensitive cases reported is still relatively small. In 1960, Di George and Auerbach knew of no more than 30 cases and only a few have been reported since then. We therefore describe two further cases, one of which has been followed up for five years. All authors are agreed that until recently treatment has been difficult. However, the advent of diazoxide, a hyperglycaemic benzothiadiazine derivative, may in future make treatinent easier. Our two patients were given this drug and we report the clinical results together with observations of its effect upon blood insulin levels.